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Biography

Brian received his Ph.D. at the Swiss Federal Institute of Technology in Zurich (ETHZ) utilizing pre-clinical models to assess the influence of multiple genes on the development of host immunity. He conducted a postdoctoral fellowship at the South African Tuberculosis Vaccine Initiative (SATVI) where in addition to performing research and supervising students, Brian co-led the immunological assessment of a novel TB vaccine in clinical trials and coordinated a training program for international immunology researchers involved in a new pediatric TB/ HIV study.

Abstract

The Clinical Immunomonitoring Platform at the Singapore Immunology Network (SIgN) is dedicated to defining immunomarkers and immunological endpoints with clinically relevant impact via high-throughput acquisition of immunological data from cohort studies and clinical trials. The žPlatform leverages on the scientific expertise of SIgN’s Principal Investigators (PI) supported by a suite of capabilities including the following facilities: Flow Cytometry/ FACS/ Luminex, CyTOF, Functional Genomics, and a comprehensive Bioinformatics team.
The Platform is routinely involved from the initial stages of study design to sample processing, biobanking, assay running and downstream analysis. The complex datasets generated from the measurement of immune and clinical parameters are integrated into the translational data warehousing system, TranSMART, analyzed using well-established pipelines, and interpreted. The Platform has a well-defined workflow and project management infrastructure, which is capable of engaging all phases of research from early discovery all the way up to the assessment of Phase IV clinical trials. The Platform’s capabilities can be exploited to yield outcomes spanning diverse applications including biomarker discovery, target identification and the assessment of vaccine clinical trials. Examples of current clinical trial studies conducted by the Platform include (i) The assessment of immunosenescence and responsiveness to Influenza vaccination in the elderly and (ii) An investigation of the microbiome and host immune modulation during treatment with different antibiotic regimens.