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Biography

Chunxia Su has completed his PhD at the age of 30 years from Nanjing Agriculture University.She has published more than 10 papers in reputed journals

Abstract

IL-2 is one of the most extensively used adjuvants for vaccination to stimulate the proliferation and differentiation of effector T cells.Follicular helper T cells (Tfh cells)are a new CD4+T cell subset that specializes in helpingformation of germinal center (GC) and, consequently, mediated the T-dependent humoral immunity response. However, it is uncertain whetherIL-2 as an adjuvant may modulate the Tfh cells immune response. In this study, we investigated the effects of IL-2 adjuvant for adenovirus-vectored FMD vaccine on production of FMDV VP1 specific IgG,IgG1 and IgG2a, secretion of IFN-γ,IL-4 and IL-21 in serum, expression of Bcl-6 mRNA from mice after immunization. Further, we explored the generation of Tfh cells, GC B cells and formation of GC from mice after immunization. The data showed that IL-2 as an adjuvant for adenovirus-vectored FMD vaccineenhanced both levels of antibodies and secretion of IFN-γ,IL-4 and IL-21 in serum, which revealed the potent adjuvant activity of IL-2 could enhance the generation of Th1(IFN-γ) and Th2(IL-4), as well as Tfh(IL-21) cells. The further effects of IL-2 on Tfh cells were detected and showedthat IL-2 as an adjuvant for adenovirus-vectored FMD vaccine increased the generation of Tfh cells and the expression of Bcl-6 mRNA, additionally, IL-2 as an adjuvant for adenovirus-vectored FMD vaccine substantially increasedthe generation of GC B cells and formation of GCs, which revealed that IL-2 as an adjuvant for vaccination induced generation of Tfh cells and then mediated T-dependent humoral immunity response.

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