Dora Maria Grassi Kassisse graduated in Pharmaceutical Sciences (PUC-Campinas1986), master’s in Biological Sciences (Physiologist, State University of Campinas-Unicamp, 1990) and Ph.D. in Biological Sciences (Pharmacologist, University of São Paulo-USP, 1994). She conducted her fi rst post-doctoral in Brazil (stress and phytotherapy-FAPESP support) and second in metabolism area at Universitè Claude Bernard Lyon- France, (adipocytes isolated from humans and rats-FAPESP support). She is Professor at UNICAMP since 1997 and has experience in the area of physiology, with emphasis on endocrine physiology and metabolism, acting on the following subjects: effi cacy of drug therapies and physiotherapy practices in humans and laboratory animals and also in vascular reactivity and isolated adipocytes and stress.


Our studies began showing that rats treated with aqueous extract of Croton cajucara Benth increased stimulated lipolysis. Currently, we study the eff ectiveness of treatment for chronic anti-stress manual therapy (MT) and the eff ects of a single session of manual lymph drainage (MLD) in humans. Th e objective of this study was to evaluate the perceived stress using questionnaire (PSQ), variability of heart rate (VHR) to assess the sympathetic (S, LF) and parasympathetic (PS, HF) tonus and collect urine to analyze the electrolyte balance in the volunteers. Treatment with MT was eff ective in reducing stress, as observed with a decrease in HR and values of QEP. Th e MLD was eff ective in maintaining sodium excretion in women not using oral contraceptives (OC) while in OC we observed increasing amount of water excreted. Moreover, independent of the users, MLD increased LF/HF ratio, indicating an increase in S and decrease in PS. In pigs, the effi ciency of massage therapy and caff eine on lipolysis was evaluated. Th e massage therapy facilitated lipolysis and caff eine applied topically for 15 days was eff ective in increasing lipolysis only with the use of ultrasound. Th e eff ect of supplementation with aqueous extract of Siberian Ginseng (SG) was assessed morphology of adipocytes isolated from rat fat pads trained or not. SG treatment was eff ective in reducing the area of the rat epididymal adipocytes untrained and reduce the area of mesenteric adipocytes from both groups trained or not. We conclude that it is possible to scientifi cally validate the effi cacy of physical therapy treatments or medicated common in clinical aesthetic.

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