Eka Sunarwidhi Prasedya
Fukushima Medical University, Japan
Eka Sunarwidhi Prasedya comp-leted his Master degree from IOES, University of Malaya, Indonesia. Now he is a PH.D. scholar at Istitute of Medicine - Department of Physiology and Integrative Studies, Fukushima Medical University, Japan. He has 3 years of research experience and published more than 4 research papers.
Vanadium is distributed extensively in nature. Disposition of vanadium in specific tissues may be involved in the pathogenesis of certain neurological disorders and cardiovascular diseases. Vanadium belongs to the group of oxyanions, which are a group of chemical compounds with a generic AxOyz−. In this study, vanadium with 6 different concentrations 1µM, 3µM, 10µM, 30µM, 100µM, and 300µM was applied to 5 different cell lines, Hela, caco2, HEPG2, HEK293, and SY5Y. The cell amount exponentially decreased for all cell lines in 3 days. However the cell death rate for each cell line is different. Hence the oxyanion pathway of each cell lines probably has different properties. In this research we try to find whether the oxyanion channels are regulated by the SLC26A gene family. The oxyanion pathway is still poorly understood, but we assume that since oxyanion is an anion, it probably has the same pathway as other anions. The anion channels are likely to be regulated by the human solute carrier 26 family ( SLC26A gene family). A big gene family with 11 isoforms from SLC26A1 to SLC26A11.