University of Milano, Italy
Elisabetta Ranucci has completed his PhDin Chemistry atthe University of Pisa, Italy, and postdoctoral studies at the University of Brescia. He has worked at the Royal Institute of Technology in Stokholm from 1998 to 2001, were she was appointed “Docent” in Polymer Chemistry. She is currently serving as full professor of Polymer Chemistry at the University of Milan, Italy.She has published more than 125 papers in reputed journals and filed more than 15 patents.Her main research interest is the design of new bioactive and biocompatible polymers for biotechnological applications.
The aim of this work is to present a one-pot synthetic process leading to poly(lactide-co-glycolide)-g-poly(vinylpyrrolidone) (PLGA-g-PVP) copolymers consisting of high molecular weight PLGA carrying oligomeric PVP side chains. The title copolymers were prepared by chain transfer radical polymerization of N-vinylpyrrolidone in the presence of 50:50 PLGA, acting as polymeric chain transfer agent in the absence of solvents. All copolymers were characterized by1H-NMR (400 MHz), FT-IR, SEC, MALDI-TOF, DSC, TGAand DLS techniques.PLGA is a lipophilic biodegradable polymer, whereas PVP is hydrophilic, biocompatible and also bioeliminable for molecular weights < 40.000. Both polymers have been approved for human use by the U.S. Food and Drug Administration, therefore the PLGA-g-PVP copolymers are eligible for medical applications. The water-soluble PVP portion imparts amphiphilicity to the otherwise hydrophobic PLGA, thus modifying its behavior in aqueous systems. In particular, PLGA-g-PVP samples spontaneously form nanoparticles when dispersed in water. These nanoparticles, besides dissolving hydrophobic drugs, for instance antimalarial drugs, in the inner core, are expected to show higher compatibility than native PLGA towards many drugs known to interact with PVP. In addition, PLGA-g-PVP samples, when used as additives, dramatically improved wettability of hydrophobic materials, as for instance polyesters, processed as nanofibers and intended for applications involving contact with the body fluids.