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Elvira Hermawati

Bandung Institute of Technology, Indonesia

Title: Secondary metabolites of endophytic fungi from Morus plant

Biography

Elvira has received her master degree in chemistry (2011) from Chemistry Department, Institut Teknologi Bandung. Her research is about isolation of medicinal plants and their activities. She joined Natural Product Research Group of Institut Teknologi Bandung. Now, she is still carrying out doctoral program in Institut Teknologi Bandung and currently working with isolation of secondary metabolites from endophytic fungi.

Abstract

Endophytic fungi are defined as fungi that reside in the tissues of living plants, and to be a promising source of bioactive compounds including anticancer, anti-inflammatory, neuroprotective and antioxidant. Morus plants, or locally known as “murbei”, have been widely cultivated for feeding silkworm in silk industry in many countries and widely known can be used as a traditional drug. Phytochemistry study showed that these plants produced phenolic compounds mainly stilbenes, 2-arylbenzofurans, and flavonoids. Three endophytic fungi, Talaromyces wortmanii, Xylaria sp, and one unidentified endophytic fungi were isolated from Morus cathayana and Morus macroura. Wortminn and skyrin are two known compounds that successfully isolated from Talaromyces wortmanii, while, 19,20-epoxycytochalasin Q, 18-deoxy-19,20-epoxycytochalasin Q, 19,20-epoxycytochalasin C were isolated from Xylaria sp. On the other hand, three new compounds also have been isolated from unidentified fungi, namely two arthrinone derivatives and a presilphiperfoliane sesquiterpene. Cytotoxic evaluation of these compounds showed that 19,20-epoxycytochalasin Q exhibited the most active cytotoxicity with IC50 < 0,1 μg/mL against murine leukemia P-388. It showed that endophytic fungi are microorganisms that can be an alternative source of bioactive secondary metabolites.