Inonu University, Turkey
Emrah Otan is neurosurgeon in the Department of Neurology, Inönü University Faculty of Medicine, Malatya, Turkey. He has 17 publications and his research interests includes brain aneurysm, neurosurgery, brain tumoour.
Objective: Liver transplantation is among the outstanding treatment options of end stage liver disease. As a result of the limited organ donation in our country, living donor liver transplantation (LDLT) is performed more frequently. Neurological complications contribute to poor post-operative outcomes following liver transplantation. Our objective is to evaluate the results of neurological complications observed during post-operative intensive care unit follow-up of LDLT patients. Patients and Method: Among the 217 LDLT operations performed between August 2011 and August 2012, neurology consultation was performed for 29 patients (13.36%) due to neurological symptoms. Data of age, sex, primary disease, MELD score, post-operative hospitalisation duration of patients survived were collected retrospectively. Consultation indications and diagnoses were categorised into the groups of acute confussionel state/encephalopathy, epileptic seizures, leucoencephalopathy and focal neurological deficits. Immunsupressive treatment regimens were also examined. Results: Mean age was 44.52±16.24 and there was a male dominence (65.5%, n=19). Acute confussionel state/encephalopathy was the most frequent complication (62.1%, n=18), followed by epileptic seizure (27.6%, n=8), focal neurologic defitics (6.9%, n=2) and leucoencephalopathy (3.4%, n=1). Mortality was significantly high when compared with the overall mortality among patients without neurological complications (65.5% vs. 37.32%, p<0.001). Post-operative hospitalisation duration was significantly extended in the patients with neurological complications group (10.00±5.47 days vs. 29.80±15.04 days, p<0.001). Mortality is significantly high and post-operative hospitalisation duration is significantly extended among LDLT patients with neurological complications.
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