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Biography

Evrim Yenilmez has completed her PhD at the age of 28 years at Anadolu University Faculty of Pharmacy, Pharmaceutical Technology Department in Turkey. Since 2007, she is Assistant Professor in Pharmaceutical Technology Department, she is a lecturer and researcher. Her research is focused on Nanotechnology; Drug Delivery and Cosmetic Delivery Systems. She has attended several Symposiums with oral and posterpresentations. She also contributes Pharmaceutical Journals as an active reviewer.

Abstract

Macrolide antibiotics constitute a very important class of antibacterial compounds. They are used to treat a wide range of infections, not only inmedical but also in veterinary practices.Macrolide antibiotics have chemical characteristics different from otherantibiotics, such as having macrocyclic lactone, peculiar molecular size and conformation, and high lipophilicity. Dirithromycin (DRM) is a newer macrolide or new generation macrolide, showingbroader antibacterial spectra and good bioavailability through acid stability. Skin and soft tissue infections (SSTIs) have become the second most common type of infections.DRM is as effective as penicillin against skin and soft-tissue infections. DRM appears tohave a similar incidence of gastrointestinal sideeffects. Because of the known side effects, it will be safe to use DRM as topical agent. However, the transdermal penetration and systemicbioavailability of topical macrolides are not yet completely clarified. In order to enhance topical or transdermal delivery of activepharmaceutical ingredients, many drug delivery systems, such asliposomes, polymeric or lipid nanoparticles (NPs) and microparticles, have been extensively studied. In this study polymeric nanoparticles were prepared and characterized for topical use aiming to havelocalized treatment and controlled antimicrobial delivery.