Giuseppina Messina

International Integrative Medicine, Italy

Title: Psychoneuroendocrinoimmunology and cancer: Psychoimmunological evaluation and prognosis in cancer disease


Giusy Messina took her graduate degree in Clinical Psychology from the University of Milan. She is specialized in Psychotherapy from the School of Medicine of the University of Milan. She is working in the clinic with patients and her research area is Psychoneuroendocrinoimmunology and her main research focus is the relation between the psychic condition and the psychoneuroimmunologic of cancer patients using the projective Rorschach’s test. She is author of more than 100 scientific publications on international and Italian journals. She is Associate Member of International Psycho-Oncology Society and of World Psychiatric Association


Thanks to the discoveries of psychoneuroendocrinoimmunology, we now know that every psychological state is mediated by a specific neurochemical condition and every neurochemical change in turn influences psychological status. We can now identify three different levels of neurochemical mediation of the psychological states: neurotransmission, neuromodulation, and the psychoneuromodulation. Neurotransmission is composed of five main neural pathways, noradrenaline, acetylcholine, dopamine, serotonin, and histamine; neuromodulation; and the psychoneuromodulation. We have performed several clinical studies in an attempt to correlate the psychological status of cancer patients with the immune alterations characteristic of the clinical history of neoplastic disease. We have studied the immunologic status by evaluating cytokine blood levels and the lymphocyte subpopulation; the psychological status was assessed by the Rorschach’s test; and spiritual status was evaluated by a previously published test to explore spiritual faith. These preliminary psychological studies seem to suggest that a pretreatment analysis of psychological and spiritual status may predict the efficacy of both chemotherapy and immunotherapy in advanced cancer patients.

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