Hala M. Abdelkarem
Al Gouf University, Saudi Arabia
Hala M. Abdelkarem has a special interest in obese, diabetes, osteoporosis and nutritionally-related health problems. Able to explain their pathophysiology. Special interested in aspects of numerous biochemical analysis in biological fluids. Teach lecture of biochemistry, estimation of nutritional elements, vitamins and hormones in blood fluids. The chemical and biological evaluation in dietary nutrition. Studies of different methodology to evaluate the nutrition status in patients. Estimation of bone markers in the biological fluids. She is the member of nutrition council at minster of Health, Egypt. Member of scientists council, Egypt. Member molecular biology and biochemistry council, Faculty of medicine, Ain Shams University, Egypt. Member of diabetic and endocrinology council, Diabetic institute, Minister of Health, Egypt. Member of medicinal council, National Research Center, Egypt.
Background: The metabolic syndrome (MetS) is a constellation of risk factors, including impaired fasting glucose, hypertension, central adiposity, predisposing to higher risks of oxidative stress, type 2 diabetes and atherosclerotic cardiovascular disease (CVD). Obesity/insulin resistance is associated with metabolic syndrome, which plays a pivotal role in cardiovascular risk. The mechanisms that link obesity, insulin resistance, and endothelial dysfunction are numerous and complex Increase in visceral fat, usually involved in obesity, leads to an imbalanced production of metabolic products, hormones, and adipocytokines including tumor necrosis factor-alpha (TNF-alpha), free fatty acids (FFAs) or adiponectin which causes decreased insulin sensitivity in skeletal muscle and liver, and impairs endothelial function through direct or indirect mechanisms.
Objective: The purpose of this study is to assess the beneficial effect of quercetin, flaxseed and/or in combination as synergetic in an animal model of metabolic syndrome (MtS), high fructose (HF) -fed rats.
Methods: Fifty male Sprague-Dawley rats, 3-month old and weighing between 110-120g were randomly divided into 5 groups. Rats were given drinking water (-ve control rats) or 10% fructose in drinking water (HF; fructose-fed rats) with standard chow for 8 wk. After 4-wk HF feeding, rats were further divided into matched 4 subgroups. Different groups of animals (n-10, each group) were administered; 10% HF (5 mg/kg, + ve control), flaxseed (F; 50 mg/kg), quercetin (Q; 50 mg/kg), flaxseed+quercetin, (FQ; 25 mg/kg of each) respectively. All ingredients were given orally once daily and subsequent 4 wk. Serum glucose, insulin, lipids profile, leptin, and adiponectin were estimated.
Results: After 4 weeks of feeding, a significant increase in blood glucose level was observed in HF fed rats compared to normal rats, but this increase was significantly decreased after administration of F, Q & FQ. The raised of serum insulin level in HF fed rats was significantly decreased after administration of F and FQ groups. Significantly higher concentrations of triacylglycerols (TG), total cholesterol & low density lipoprotein cholesterol (LDL-C) were observed in HF fed rats and these increases were lower after administration of F, Q & FQ. There was a significant increase in serum high density lipoprotein cholesterol (HDL-C) in FQ group. The increased of serum leptin level was decreased significantly in F, Q & FQ groups. Whereas the reduction of serum adiponectin level in HF fed rats was increased in F, Q & FQ groups.
Conclusion: These data suggested that protective effect of flaxseed and quercetin consumption as functional foods could be reduced risk for people with decreased insulin sensitivity and increased oxidative stress, such as those with the metabolic syndrome or type 2 diabetes.