University of North Texas Health Science Center, Texas
In woo Park is currently working as Associate Professor in department of Cell Biology and Immunology, UNTHSC (University of North Texas Health Science Center). 2011 - 2013 Research Associate Professor Cell Biology and Anatomy, UNTHSC, 2007 - 2011 Research Assistant Professor Microbiology and Immunology, Indiana Uni. Sch. of Medicine, 1996 - 2007 Instructor Experimental Medicine, Harvard Medical School. He is also a member of Radiation Safety Committee.
The precise molecular mechanisms on how HIV-1 co-infection accelerates HCV-mediated liver disease progression are currently unknown. Our data showed that infectious HIV-1 virus particles failed to enter into human hepatocytic cell lines, and discernible virus replication was not observed, even when the hepatocytes transfected with HIV-1 proviral DNA were co-cultured with Jurkat T cells, suggesting that liver deterioration in the co-infected patients is not due to the replication of HIV-1 in the hepatocytes. Instead, HIV-1 Nef protein can be transferred from nef-expressing or HIV-1-infected cells to hepatocytes through conduits, not exosomes, and the transferred Nef in the target hepatocytes altered lipid droplet formation, up-regulated subgenomic replicon expression of HCV, augmented reactive oxygen species (ROS) production, and enhanced ethanol-mediated up-regulation of HCV replication. Taken together, these data indicate that HIV-1 Nef plays an integral role in expedition of liver pathogenesis in the HIV-1/HCV co-infected hosts.
Speaker PPTsDownload PPT