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Irina Magdalena Dumitru

Irina Magdalena Dumitru

Ovidius University Romania

Title: Toxoplasmosis in immunocompetent and immuno compromised population of Constanta, Romania

Biography

MD, PhD, Associate Professor in the “Ovidius” University, Constanta, Faculty of Medicine, Senior Specialist, Director of research and development (2006 – 2010). I am president of the Romanian Association of Parasitology, Constanta. In recent years I am focused on the parasitological, tropical diseases, chronic hepatitis and HIV/AIDS research. In present I am NCP Health Romania for Horizon 2020 program. I am involved in many research projects and I have published numerous scientific articles.

Abstract

Introduction: Toxoplasmosis, an infection with a worldwide distribution, is caused by the intracellular protozoan parasite, Toxoplasma gondii. Material and methods: Were analyzed a total of 386 adult patients diagnosed with toxoplasmosis in the Infectious Diseases Hospital in the last 5 years. Results: Of these patients, 85% were from urban area, 77% female; majority aged 30-49 years. 3% were diagnosed with HIV infection (12 patients), in three of these patients, toxoplasmosis was the primary clinical manifestation. The most common clinical manifestation in non HIV infected patients was painless cervical adenopathy (102 patients), followed by flulike symptoms and generalized lymphadenopathy (6 patients), retroperitoneal and mesenteric lymphadenopathy with abdominal pain (8 patients), seizures, persistent headache (32 patients), retinochoroiditis (12 patients), pulmonary involvement (4 patients), cerebral toxoplasmosis (mass lesions) only in a female with chronic hepatitis B and non Hodgkin lymphoma. 56 pregnant women (5 with acute infection and 51 with chronic infection were followed during pregnancy), 43 patients had associated infection with Toxocara and were presented to the hospital for itchy rash. No clinical symptoms were observed in other immunocompetent patients, toxoplasma infection was diagnosed incidentally. In HIV infected patients prevailed cerebral toxoplasmosis (toxoplasmic encephalitis, with or without focal CNS lesions), only one patient presented generalized lymphadenopathy and pulmonary involvement. Conclusion: Reporting the number of cases of toxoplasma infection in Constanta population (254.693 inhabitants), we obtain a prevalence of 151.5 cases/100.000 inhabitants. Most patients were female and their supervision is required for possible implications in pregnancy. We believe that Toxoplasma infection is under diagnosed in our county.

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