Kunming Institute of Zoology, China
Jian Hong Wang has completed her Ph.D. in 2007 in the Kunming Institute of Zoology, CAS., and postdoctoral studies from the Institute of Neurobiology, Freie Universität Berlin, Germany, and the Developmental Biology Laboratory, Université Pierre et Marie Curie-Paris VI, France. She has published 24 papers in the international journals, major on the topic of learning and memory, and addiction.
Addiction is a kind of abnormal learning and memory. The difference in mechanism between the addiction associated memory and normal memory is still unclear. Especially, how to reduce the relapse is a serious social problem. One of our interests has been focused on addiction research using both rodents and non-human primates as the animal models. Our current results are: those influence normal learning and memory, including blocking cholinergical system by scopolamine, inhibiting protein synthesis and the electric shock after conditioning of CPP (conditioned place preference) failed to impair (even has reverse effects on) the learning and memory associated with morphine reward in mice. Thus, the learning and memory related to the addiction is quite complex. In addition, we built a CPP in rhesus monkeys and found that the memory associated with morphine treatment could last at least 36.3±1.3 months after the conditioning. In these monkeys, we study if the insula contributes to the retrieval of morphine associated memory. One of our primary findings is that temporarily inactivating the bilateral insula by lidocaine (5%, 40ul) blocked the expression of the retrieval of CPP in one monkey, but not in other four monkeys. In addition, no effect was found in the working memory when these monkeys were tested the delayed response by using a WGTA task after the morphine treatment.