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Biography

Mrs. Jyoti P. Jadhav is currently working as a Professor and Head of Department of Biotechnology at Shivaji University, Kolhapur. She has received her doctorate degree in Biochemistry in 2000 and has made several noteworthy contributions in understanding enzymatic pathways involved in bioremediation of hazardous compounds and biotransformation of bioactive molecules. Her research encompasses the study of enzymes for the predication of metabolic pathways for textile dye degradation followed by cytotoxicity, genotoxicity assays to analyze toxic nature of dye and its degradation metabolites. Her research contributions will help the successful and ecofriendly treatments of effluent wastes. She and her student have standardized a protocol of feather degradation and enzymatic leather dehairing using bacterial keratinases also feather waste as bioenhancer. Additionally, studies on mechanism of conversion of L-DOPA and melanin in bacterial and plant systems and synthesis of Indole-3-acetic acid using bacteria have been pursued by her and her students. She has published 69 research papers in international and national peer reviewed journals and obtained one international patent on the Melanin production and L-DOPA. She has presented more than 55 papers in international and national conferences and has given plenary lectures in international conferences. On the basis of her research credentials recently she has been awarded with Young women scientist award BRSI (2011) and Fellow of Maharashtra Academy of Sciences (2011). Currently she is working on the research project that involves use of herbal extracts for the treatment of Parkinson's disease.

Abstract

The Parkinson's disease is a neurological disorder associated with an underproduction of dopamine in the human brain. L-DOPA (3, 4 dihydroxyphenyl-L-alanine) is a well known sympathetic stimulant and being used for symptomatic relief of Parkinson's disease. The conventional process used in the production of this drug generates both optical and chemical impurities that make it unsuitable for medication. Naturally L-DOPA is found in certain plant foods, particularly broad beans which found to replenish brain levels of L-DOPA more rapidly and for longer periods. Different biological sources yielded maximum amount of enantiometrically pure L-DOPA under statistically optimized cultural conditions. Bacterial isolates used in our study showed utmost production of L-DOPA were Bacillus sp. JPJ (11.02 g l-1), Brevundimonas sp. SGJ (3.35 g l-1), Pseudomonas sp. SSA (3.25 g l-1) and Yarrowia lipolytica (4.09 g l-1).While in plants, Mucuna monosperma seeds collected from the local area showed 118 mg g-1 of L-DOPA per gram of dry seed. Similarly, other local species of Mucuna and green leafy vegetables that are consumed regularly showed higher content of L-DOPA can be a promising candidate for the treatment of Parkinson's disease. As these plants were found to contain phenolics that play the important role as antioxidants, antimutagens and scavengers of free radicals produced during the oxidative stress. Biological synthesis of L-DOPA will be the most promising approach to overcome the classical methods used in chemical drugs formulations; natural sources reduces the secondary complications which will helps to delay the progression of the disease. The alternative sources of L-DOPA and a further clinical trial will open the subject of extensive research.

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