Chinese Academy of Sciences, China
Fang graduated from Lanzhou University in 1994 and received her Ph.D from the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences in 2003. She got her postdoctoral training at Fox Chase Cancer Center from 2003 to 2008. She worked as a research associate and then as a staff scientist at Fox Chase Cancer Center from 2008 to 2012. She joined the Institute of Microbiology, CAS as a professor supported by “Thousand Young Talents Program” of the China’s government in 2012.
Although traditionally classified as cells of the innate system, recent studies have shown the NK cells generate antigen-specific memory during viral infection or vaccination, and protect against subsequent viral infections. We recently discovered that CD94-NKG2E, another NK cell activating receptor, recognize ectromelia virus infected cells in the context of the non-classical MHC class I molecule Qa-1b. We want to detect anti-ECTV specific NK cell memory during viral infection.In the long term, we also want to explore the molecular and cellular mechanisms involved in the generation and maintenance of NK cell memory, relevant to development of vaccination strategies.
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