Dr. Ming Li is a Principal Scientist in the Translational Sciences Department at Biogen Idec, Inc., in Cambridge, MA. Formerly, he was Principal Scientist, Technology Development and Implementation at Pharmacokinetics Dynamics and Metabolism, Pfizer Global Research and Development in Groton, CT, and before that Research Scientist II at DMPK, Roche Palo Alto in Palo Alto, CA. Dr. Li received his B.S. in Polymer Science from Fudan University in Shanghai, China and Ph.D. in Analytical Chemistry from State University of New York at Buffalo (UB). His recent research interest and publications are in the area of bioanalytical laboratory automation.


Bioanalytical sample preparation automation has been gaining momentum for many years now, with reliable and robust automated assays being developed for most types of typical extraction procedures. With routine sample preparations being automated, the next bottleneck in the bioanalytical workflow is sample preparation method development, which is still largely done manually as of now. On the horizon is the sample preparation method development automation, which promises to further streamline workflows and further reduce manual routine bioanalytical bench work. This trend is still in its infancy, and dedicated development staff is recommended to nurture successful application. Herein we present our recent work in the automation of the small molecule bioanalytical sample preparation method development.