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Biography

Mohammed Alsaif graduated from King Saud University Riyadh and in August 1989 to July 1990: Worked as a Rotating Intern in King Khalid University hospital and affiliated hospitals with an overall “excellent” evaluation. The internship year included: three months of Internal medicine, three months of surgery, three months of obstetrics and gynecology, and three months of pediatrics. From August 1990 to october 1992 he worked as a resident in the department of dermatology at Prince Salman Hospital . He has done training for diploma in dermatology and veneriology at the Department of dermatology, King Saudi University. He worked as assistant professor of dermatology Department of dermatology, King Saud University. He worked as director at King Saud University Fellowship for (postgraduate)training program in dermatology.

Abstract

To investigate the antihyperlipidemic effect of crude ethanolic extract of Melothria maderaspatana (M. maderaspatana) leaf (CEEM) on deoxycorticosterone acetate (DOCA)-salt hypertensive rats. A midscapular incision was made on each rat and the left kidney was excised after ligation of the renal artery. The surgical wound was closed using an absorbable suture. After one week recovery period, hypertension was induced by subcutaneous injection of DOCA-salt solution, twice a week, and the rats received a 1% sodium chloride solution as drinking water throughout the experimental period. CEEM or nifedipine was administered orally once a day for 6 weeks. In DOCA-salt hypertensive rats, the level of plasma and tissues of total cholesterol (TC), triglycerides (TG), free fatty acids (FFA) and phospholipids (PL) significantly increased and administration of CEEM significantly reduced these parameters towards normality. Further, the levels of low density lipoprotein-cholesterol (LDL-C) and very low density lipoprotein-cholesterol (VLDL-C) significantly increased while high density lipoproteincholesterol (HDL-C) decreased in hypertensive rats and administration of CEEM brought these parameters to normality which proved their antihyperlipidemic action. Histopathology of liver, kidney and heart on DOCA-salt induced rats treated with CEEM showed reduced the damages towards normal histology. These findings provided evidence that CEEM was found to be protecting the liver, kidney and heart against DOCA-salt administration and the protective effect could attribute to its antihyperlipidemic activities.

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