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Mohanad A. Al-Bayati

University of Baghdad, Iraq

Title: The effect of L-arginine on mice placenta

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Abstract

L-arginine-nitric oxide pathway has emerged as novel regulators of several vital roles in the reproductive function comprise pregnancy events, such as placental development. This study was done to pharmacologically enhance the performance of female reproductivesystem by using L-arginine powder as forerunner of nitric oxide. The study protocol consists of total number of96 pregnant mice divided into two main groups equally (48 animals per group) and handled as follows: 1th Control group given normal saline orally daily and2nd L-arginine dosed group 200mg/kgBW 20% orally daily,both groups were randomly divided into four subgroup according to dosed period of pregnancy term, the dosed period were 1-15 days, 7-15 days, 7-21 days and 15-21 days. Several parameters were valuated and displayed the following results: L-arginineconcentration % in uterine tissue was elevated their levels associated withincrease body, uterine, placenta and fetus weights. That presumably was controlled by an increase food and water intakes well as hormonal levels (estrogen and progesterone) mainly at7-21 days and15-21 days of gestation dosed periods.Those results proved changes inthe histological and stereological profile was illustrated the activity and enlargement of placental layers acquaintance with increasing blood vessels (angiogenesis and vasodilation) and vascular density (%) in especially in7-21and 15-21of dosed gestation periods led to anincrease placental volume and geometric parameters(cm), weight(gm) and proportionalthickness (cm), vascular density, blood vessels.Fetal traits parameters, displayed uppermost statistically values of fetuses and weights in all gestation periods expressly in periods (15-21) achieved best results. Also increases the other parameters: blood volume, steriometry values, histological assessments and alkaline phosphatase and lactogens values. The endpoints of this study presented the L-arginine donated NO which was capable of increasing remodeling blood supply and improvement of some reproductive phenotypic of animal models and superior to the produced vital fetuses.

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