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Nadeem A. Kizilbash

Nadeem A. Kizilbash

Department of Biochemistry, Faculty of Medicine & Applied Medical Sciences, Northern Border University, Saudi Arabia

Title: Predicted Structural Elements of Bcr-Abl Oncoprotein Isoforms in Chronic Myelogenous Leukemia

Biography

Dr. Nadeem Kizilbash received his Bachelor’s degree in Chemistry from Longwood College in U.S.A. His Master’s degree was also in Chemistry from Washington University in St. Louis, U.S.A. His doctoral degree was awarded in Biophysics from Boston University in U.S.A. He is presently working as an Assistant Professor of Biochemistry at Northern Border University in Arar, Saudi Arabia. He has published fifteen papers in various journals on topics as diverse as Proteomics, Protein Structure, Drug Delivery and Gene Polymorphism. Dr. Kizilbash is currently a member of editorial board of three international research journals.

Abstract

The structural elements of Bcr-Abl oncoprotein (p210BCR-ABL) isoforms, b2a2 and b3a2, expressed in Chronic Myelogenous Leukemia (CML), were predicted by Psipred and ExPASy servers. These proteins are tyrosine kinases with masses of 210-kDa. Structural differences were found in five -helices (25, ', 26, 27 and 29) and nine β-strands (β12, β13, β15, β', β17, β30, β", β34 and β35). These differences are present in the SH3, SH2, SH1 and DNA-binding domains. The structural differences might be able to explain the different roles played by the two isoforms in mediating signal transduction during the development of CML