Ozlem Gurses Sahin
Dunya Goz Hospital, Turkey
Ozlem Gurses Sahin received her M.D. from Hacettepe University Medical Faculty, Ankara, Turkey (1983-1989); she did her Clinical and Research Fellowship in Uveitis and Ocular Immunology (1997-2000) from The University of Illinois at Chicago, Eye and Ear Infi rmary Department of Ophthalmology, Chicago, Illinois, USA. Ozlem Gurses Sahin, MD is Specialist in Ophthalmology/Uveitis and Ocular Immunology. She is also a reviewer for the International Journal of Medicine and Medical Science.
The purpose of this study is to disclose the adjunctive role of methotrexate for the posterior segment manifestations of FTAABS positive cases and Quantiferon positive cases showing partial resolution with specific therapy. Methods: 3 cases with FTAABS positive, VDRL and HIV negative, and 4 cases with Quantiferon positive and HIV negative status received either oral methotrexate for 6 months or intravitreal methotrexate injections aft er discontinuation or reduction of specifi c therapy. Flourescein angiography (FANG) and spectral domain optical coherence tomography (SD OCT)were used for the clinical follow-up. Th e follow-up period aft er cessation of methotrexate ranges from 6 months to 3 years. Results: Th e resolution of posterior segment manifestations both clinically and on FANG and SD OCT were noted. Conclusions: Adjunctive therapy with methotrexate is considered eff ective for the improvement posterior segment manifestations of FTAABS positive cases and Quantiferon positive cases having partial response to the specific therapy.