Paloma Manea

Paloma Manea

Grigore T. Popa University of Medicine and Pharmacy, Romania

Title: Comparison between C reactive protein and microalbuminuria levels for the prognosis of renovascular hypertension


Paloma Manea MD, Ph D, FACCP is a specialist in Cardiology and Internal Medicine, competence in echocardiography, lecturer at ’’Grigore T.Popa’’ University of Medicine and Pharmacy, Iasi, Romania. In 2013, she discovered the 6th case (there are only 5 communicated cases, worldwide) of spontaneous closure of an interventricular septal defect after a myocardial infarction. She has published and communicated 80 scientific works. The main research areas are related to angiotensin-renin-aldosterone system, skin cancer, correlations between dentistry and medical diseases, geriatric pathology.


76 elderly patients with renal artery stenosis were enrolled in our 20 months study. The assesment of the patients included the following: a complete clinical examination, electrocardiogram, echocardiogram, renal artery sonography, abdominal computed tomography, laboratory findings. We’ve compared two important parameters in order to establish their role among patients’ prognosis: C reactive protein and microalbuminuria levels. Renal dysfunction (worsening of the serum creatinine clearance) was strongly correlated with high levels of C reactive protein and it had a weaker association with microalbuminuria. 92% patients with high levels of C reactive protein had dental plaque and correct removal of the plaque lead to the lowering of C reactive protein levels; this atitude (scaling) was followed by an improvement of serum creatinine clearance or at least a stable value. These observations had an impact regarding the holistic approach of renovascular hypertension and delimited new targets for a proper therapy of these patients.

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