Quan Zhou

Quan Zhou

First Affiliated Hospital of Jinan University, China

Title: The study of resting-state FMR change in primary insomnia patients based on regional homogeneity


QUAN ZHOU, as an Assistant Director of the medical imaging Centre in the first Affiliated Hospital of Jinan University (Guanzhou, Guandong province). The same time, also as a teacher of medical imaging and nuclear medicine of Jinan University, now. Having engaged in medical imaging for 24 years and good at x-ray, MRI and CT diagnostic medical imaging work. More than 40 papers published in this professional and authoritative journals. Main research interests including chest and orbital disease imaging diagnosis, functional MRimaging and molecular imaging research. His research was funded by State Education Ministry, the Natural Science Foundation of Guangdong Province, State administration of traditional Chinese medicine, and the National Natural Science Foundation of China.


Objective: Compare the difference between of primary insomnia patients and healthy volunteers groups based on regional homogeneity of cerebral in resting-state, to explore the neurobiological features of primary insomnia by using functional magnetic resonance imaging. Methods: 21 primary insomnia patients and 20 age- and sex- matched healthy volunteers were participated the fMRI scan in resting-state, and the data were analyzed by SPM software with ReHo method. To obtain the differences of brain regions between the two groups. Results: Compared with match group, The brain areas with significant higher ReHo value in primary insomnia patients were as follow: the left side of pons, right parahippocampal gyrus, left calcarine sulcus cortex, left lobus insularis cortex, bilateral anterior cingulate cortex and left precuneus; and ReHo value was significantly decreased in the bilateral of inside back of the prefrontal, bilateral cuneus, right precuneus and bilateral posterior central gyrus. Conclusion: The abnormal brain areas of primary insomnia patients are most in the struct of the limbic system, such as the back of the prefrontal, parahippocampal gyrus, cingulate gyrus, which suggesting that brain dysfunction or injury may exist in these regions. The primary insomnia patients may suffer from circadian system disorders, and we suppose that the impairment of the reticular system caused by the hyperarousal of insomnia patients are the main reason of this process.