Rasha Ahmed Elshafey has completed her PhD at the age of 36 years from Tanta University and postdoctoral studies from Tanta University School of Medicine. She has published more than 11 papers in reputed journals and serving as an editorial board member of repute
Purpose: To study possible statistically significant variations of diffusion tensor imaging quantitative parameters in detecting abnormalities in focal lesions of MS with evaluation of underlying pathology of NAWM and comparing it with NWM of control group as diagnostic elements and prognostic factors. Patients and Methods: The regional ethics committee approved the study and written informed consent were obtained from all participants. Quantitative diffusion tensor imaging (DTI) was performed in 45 consecutive MS patients, (18 men and 27 women) with a mean age of 47.3±7.9 years, 20 age-matched healthy control subjects (4 male and 6 female) referred to Radiodiagnosis Department from neuropsychiatry department from March 2012 to November 2013. Clinical diagnoses of MS were established using McDonald's criteria. Results: Mean diffusivity (MD), volume ratio (VR) and the fractional anisotropy (FA) were measured in normal appearing white matter (NAWM) and in different types of focal MS lesions during both activity and remission and compared with NAWM of control group, significant increase of the MD and decrease of FA and VR from normal white matter of the controls to normal appearing white matter of the patients to MRI detected active lesions and the least is inactive plaques. Conclusion: DTI –MRI quantitative parameters have been found to show tissue damage not only in MRI-defined lesions but also in NAWM as a result of Wallerian degeneration and helpful as diagnostic elements and prognostic tools.