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Biography

S Palani Subramani was born in a remote village, Seelappandal, which is located in the Tiruvannamalai district of Tamil Nadu State, India. He obtained his Ph.D. in the stream Biochemistry and his doctorate was awarded by the Thiruvallur University, Velllore, Tamil Nadu, India by the year 2010. He has a teaching experience of about 15 years by working as an Professor at the Department of Biotechnology, Anna Bioresearch foundation ,Arunai Engineering College before which he had been a Assistant Professor at Department of Pharmacy, Kamalakshi Pandurangan College of Pharmacy, Tiruvannamalai. He has his research experience other than this by guiding several students to perform their projects at undergraduate and post graduate levels. Proving his research quality mainly in the area of Natural Products, he has about 20 publications in several National and International Journals. He has been an invited talker on Chemistry and Biology of Antioxidants at the Sapienza Univeristy of Rome, Italy and on Natural Products and its therapeutic effi ciency at Zurich University, Switzerland whose travel grants had been supported by ICMR and DST. He has even organized a two day conference on "Natural Products and Drug Discovery" which had been supported by ICMR. He has been awarded as Outstanding Young Investigator Award-2010 by Raise.Rural organization and also for being the Best Faculty at his workplace. He carries out work mainly on knowing and analyzing the potentials of various Natural Products for the treatment of various diseases and disorders.

Abstract

Neurodegenerative diseases are oft en characterized by progressive memory loss and cognitive impairment. In traditional and Chinese medicine; numerous plants have been used to treat these cognitive disorders including neurodenerative diseases such as Alzheimers disease & Parkinson's disease. Henceforth, our research and understanding has found the neuroprotective eff ect of the extract of Cynodon dactylon in rat model. Th e aim of this study is to investigate the phytoconstituents of Cynodon dactylon by gas chromatography-mass spectroscopy (GC-MS) technique and to investigate the neuroprotective & antioxidant activities of the ethanol extract of Cynodon dactylon against diazepham induced neurotoxicity in rat brain. Th e phytoconstituents present in the extract of Cynodon dactylon were studied by GC-MS and the animals were treated with the ethanolic extract of CD at two diff erent doses (250 mg/kg and 500 mg/kg) for 15 successive days in diff erent groups of rats. Further, biochemical and histopathological observations confi rmed the benefi cial roles of ethanol extract of Cynodon dactylon against diazepham induced neurotoxicity in rat brain. Th e Diazepham signifi cantly increases the level of achetylcholinestrase, cholesterol, malondialdehyde (MDA) & superoxide dismutase (SOD) along with the reduced level of glutathione-s-transferase (GST), glutathione (GSH) & glutathione peroxidase (GPx). Th ese values are retrieved signifi cantly by the administration of ethanol extract of CD (500 mg/kg B/W) when compared with the standard drug simvastatin (5mg/kg B/W). Th us the ethanol extract of CD might serve as a reliable adjuvant for neurotoxicity, and may be promising for development of phytomedicines for antioxidant and neurodegenerative disease.

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