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Biography

Sabah Akrawi, PhD, graduated from the College of Pharmacy/University of Kentucky/USA. He is an Assoc. Prof. of Clinical Pharmacokinetic and Biopharmaceutic and a faculty member at the College of Clinical Pharmacy/King Faisal University/KSA. He supervised 17 postgraduate pharmacy students, and he has published more than 24 articles. He is a member of the scientific council of the KFU and chaired many defense committees for graduation of graduate students.

Abstract

The protective effect of L-carnitine on the gentamicin nephrotoxicity was investigated in experimental animal model. Male Wister 200-300 g rats were distributed randomly into four groups, control group, L-Carnitine treated group, gentamicin treated group, and L-carnitine + gentamicin treated group. The result showed that gentamicin nephrotoxicity in rats is detected by significant plasma creatinine, urea and zinc changes in serum and renal tissue. L-carnitine is able to ameliorate the renal functions and restore the zinc status.Zinc serum level in the gentamicin treated group is 115 µg/dl, while it is 129 µg/dl in the gentamicin + L-carnitine treated group, and zinc tissue level in the gentamicin treated group is 14.6 µg/dl, while it is 17.89 µg/dl in the gentamicin + L-carnitine treated group. The possibility of scavenging property of L-carnitine against peroxy radical is via restoring zinc status.