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Salvador Ventura

Salvador Ventura

Universitat Autònoma de Barcelona. Spain

Title: Design of aggregation resistant protein biotherapeutics

Biography

Salvador Ventura is Full Professor at the Dep. of Biochemistry and Molecular Biology and leader of the Protein Folding and Conformational Diseases group at the Institute of Biotechnology and Biomedicine, Autonomous University of Barcelona (UAB). He has authored more than 110 peer-reviewed research and review papers on protein folding and proteomics, apart from several book chapters and patents. He got his Ph. D. in Biology at the UAB in 1998 and worked as postdoctoral fellow (1999-2001) at EMBL-Heidelberg. He has been researcher at Harvard Medical School (USA) and Karolinska Institutet (Sweden) among other centres. He rejoined UAB as a Ramon y Cajal researcher in 2003. Dr. Ventura received the UAB 2008 Excellence Research Award and in 2009 the ICREA-Academia Award on Biological and Medical Sciences.

Abstract

Protein biotherapeutics emerge as promising new drugs for human disorders. However, they are extremely sensitive to stress, a major problem being the formation of aggregates during production and delivery, which impact the product quality and produce adverse immunogenic reactions. Here we introduce A3D, an evolution of the AGGRESCAN algorithm, a new tool able to predict and assist the redesign of aggregation propensity in protein 3D-structures.