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Sergei Shtykov

Sergei Shtykov

Saratov State University, Russia

Title: Supramolecular and nanobiomimetic approach to optimization of analytical reactions

Biography

Sergei Shtykov has completed his PhD from Saratov State University (SSU) in 1980 and Doctorate dissertation (Habilitation) from the SSU in 1990. From 1993 he is a Full Professor on the chair of Analytical Chemistry and Chemical Ecology of SSU. From 2005 he is a member of Division of Analytical Chemistry of the European Association for Chemical and Molecular Sciences (DAC EuCheMS). He has published more than 250 papers in academic journals and was Supervisor of 20 PhD and 8 Doctorate dissertations. His scientific direction is an application of nanoobjects, nanotechnologies and supramolecular principles in the chemical analysis.

Abstract

The base for this approach is spontaneous and self-assembly formation in the solution of different kinds of liquid nanoreactors (micelles, microemulsions, vesicles, cyclodextrins, calixarenes, LB, L-B-L films) simultaneously with the analytes and analytical reagents i.e. supramolecular effect. As a result of inclusion of the analytes and reagents into the nanoreactors, the guest microenvironment changes and provokes the change of their protolytic, tautomeric, complexing and a reactivity properties, hydration and analytical characteristics. Several features of liquid nanosystems, which are the base for their biomimetic behavior and enhancement of the analytical and metrological characteristics in chemical analysis and separation, are as follows: - the ability to concentrate and bring close together the components of analytical reaction in the nanoreactor pseudophase even though they are considerably different in hydrophobicity; - the multicenter and multifunctional noncovalent interactions of the components of nanophase with solubilized substrate; among these interactions, the hydrophobic ones plays a predominant role; - the pronounced oriented sorption and cavity effect, in which the nature and geometric compatibility of the host and guest are the decisive factors for the binding of a substrate; - the considerable microheterogeneity of the medium within nanopseudophase which manifests itself in dramatic changes in the dielectric constant, micropolarity, microacidity, microviscosity and other physicochemical properties of the unique medium with gradient of these properties. As a result, dramatic enhancements of all kinds of analytical signals in many methods takes place, and new methods are appeared. The work was supported by RFBR, project no. 12-03-00450a.