Henry Ford Health System, USA
Shailendra Giri has done his post graduate education from Medical University of South Carolina (SC) - Neurogenetics and Ph.D. from Post Graduate Institute of Medical Education & Research (India). He is the Member of the Henry Ford Medical Group and his research interests includes neurology and neuroscience.
AMPK is an energy-sensing metabolic switch implicating in various metabolic disorders. Here we report its new role in controlling the immunopathology of experimental autoimmune encephalitis by polarizing pro-inflammatory phenotype of Macrophage.AMPK alpha1 knockout (alpha1KO) developed severe EAE due to higher expression of IL17with reduced IFNy and IL4..AMPK alpha1KO also exhibited increased number of infiltrated mononuclear cells in CNS due to impaired blood brain barrier integrity. Macrophage from alpha1KO mice exhibited M1 type phenotype (IL10lowIL12/23high) with stronger capacity to induce allogenic and antigen-specific T-cell response and also heightened the encephalitogenic property of MOG35-55-primed CD4 T cells in B6 mice. Collectively, our data shows AMPK controls the clinical outcome of disease by regulating M1 phenotype-Th17 axis in animal model of MS.