Tariq Jamshaid

Tariq Jamshaid

Surge Laboratories Private Limited, Pakistan

Title: Pharmaceutics & Novel Drug Delivery Systems


Tariq Jamshaid has 11 years diversified work experience of Quality Control, Manufacturing Processes, Pharmaceutical Product Design & Development, Process Optimization, Laboratory Management, Drug Registration Processes, GMP Requirements, Drugs Laws, Statistical Methodology, Manufacturing Process Validation, Cleaning Validation, ISO 9001:2008 with strong scientific, analytical, statistical, planning, managerial and training skills. Currently, he is working as a Sr. Manager Production & Development for Surge Laboratories Private Limited, Pakistan.


Novel Drug delivery System (NDDS) refers to the approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effects. It may involve scientific site-targeting within the body, or it might involve facilitating systemic pharmacokinetics; in any case, it is typically concerned with both quantity and duration of drug presence. Novel Drug delivery is often approached via a drug's chemical formulation, but it may also involve medical devices or drug-device combination products. Drug delivery is a concept heavily integrated with dosage form and route of administration. NDDS is advanced drug delivery system which improves drug potency, control drug release to give a sustained therapeutic effect, provide greater safety, finally it is to target a drug specifically to a desired tissue. NDDS is a system for delivery of drug other than conventional drug delivery system. NDDS is a combination of advance technique and new dosage forms which are far better than conventional dosage forms. Advantages of Novel Drug Delivery System are: 1. Optimum dose at the right time and right location. 2. Efficient use of expensive drugs, excipients and reduction in production cost. 3. Beneficial to patients, better therapy, improved comfort and standard of living. Basic modes of novel drug delivery systems are: 1. Targeted Drug Delivery System 2. Controlled Drug Delivery System 3. Modulated Drug Delivery System Factors affecting the design of controlled release products are: 1. Physicochemical properties of a drug 2. Route of administration 3. Acute/Chronic therapy 4. Target sites 5. The Patient 6. The disease state/level Classification of novel drug delivery system with reference to release control is: 1. Matrix Diffusion Types (In which rate of release is controlled by diffusion of dissolved drug in the matrix). a. Rigid Matrix Diffusion (in which insoluble plastic materials like PVP & fatty acids are used. b. Swellable Matrix Diffusion (in which Hydrophilic gums like guar gum, tragacanth, HPMC, CMC, Xanthan Gum & Polyacrilamides are used). These are also called Glassy Hydrogels and popular for sustaining/control the release of highly water soluble drugs. c. Reservoir System (in which polymer content in coating, thickness of coating & hardness of micro-capsules control the release of the drug). 2. Dissolution Matrix Type (in which drug is homogeneously dispersed throughout in a rate controlling medium waxes like bees wax, carnuba wax, hydrogenated castor oil, which control the drug dissolution by controlling the rate of dissolution). a. Encapsulation (in which dissolution is controlled by dissolution controlling coating system like use of cellulose, polyethylene glycols, polymethylacrylates, and waxes. Dissolution rate also depends upon coating material stability and thickness of coating film. 3. Dissolution & Diffusion Controlled Release System (in which drug is encapsulated in partially soluble membrane, pores are created due to soluble parts of coating film which permits entry of aqueous medium into core and drug dissolution starts by diffusion of dissolved drug out of system. Mixture of water soluble PVP and water insoluble ethyl cellulose is used for this purpose). 4. Water penetration/Osmotic Pressure Controlled NDDS (in which drug may be osmotically active or drug may be combined with osmotically active salts like NaCl). 5. Chemically controlled NDDS (in which systems change their chemical nature/structure when exposed to biological fluids). 6. Hydrogels (in which three dimensional structures of hydrophilic polymers having chemical and physical cross links provide a network structure to hydrogels. These are insoluble due to network structure and provide desirable protection of liable drugs, proteins and peptides). 7. Ion Exchange Resins Controlled Release Systems (in these systems, ionisable drug is absorbed on ion-exchange resins granules then granules are coated with water permeable polymers using spray dryer technique).