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Tulliballi Shyam

Tulliballi Shyam

Dr Samuel George Institute of Pharmaceutical sciences, India

Title: A comparative study on the anti-diabetic activity of methanolic extracts of selected medicinal plants available in India

Biography

Tulliballi Shyam got awarded with doctorate from Andhra University and published more than 25 papers in reputed journals and has been serving as a reviewer of repute. He got good percentile in GATE-1999. He has been excellent in doing research with analytical techniques

Abstract

India has a rich history of using various potent herbs and herbal components for treating diabetes. Diabetes mellitus is a chronic metabolic disorder characterized by derangement in carbohydrate, fat and protein metabolism due to absolute or relative deficiency of insulin secretion. The tribal and rural population of India are highly dependent on the medicinal plant therapy for meeting their health care needs. Three Indian medicinal plants viz., Schrebera swietenoides, Barleria montana and Rotula aquatica were selected for their evaluation of antidiabetic activity against streptozotocin induced diabetic model in rats. The mean blood glucose levels and percent decrease in blood glucose levels of the above methanolic plant extracts were determined for different dose levels of 200 and 400 mg/kg b.w at various time intervals (0, 2, 4, 8, 12, 18 and 24 hrs) and compared with standard, glibenclamide. The maximum percent reduction in blood glucose levels was observed at 12th and 8th hr after oral administration of the 200 and 400 mg/kg b. w of methanolic extract of Schrebera swietenoides roots. The oral administration of 400 mg/kg b. w of methanolic extract of Barleria montana aerial parts produced highly significant (P<0.01) decrease in blood glucose level at 4 and 8th hrs. The percent reduction in blood glucose level shown by Rotula aquatica was promising and statistically significant from 2nd hr onwards indicating that the extract is fast acting. Hence it was concluded that among the three plants tested the roots of Rotula aquatica have been useful in the treatment of diabetes.

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