Wei huang is a attending physicianof Department of Radiation Oncology,Shandong Cancer Hospital &Institute,Jinan, China. Now, he is a visitor scholar, Department of Radiation Oncology, Medical College of Wisconsin.He has published more than 20 papers in reputed journals.
Purpose: The aim of this study is to investigate the value of [18F] fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) to predict recurrence of patients with locally advanced non-small cell lung cancer (NSCLC) during the early stage of concurrent chemoradiotherapy (CCRT). Methods: A total of 53 patients were enrolled in the prospective study. All patients were evaluated by FDG PET before and following 40 Gy radiotherapy (RT) with a concurrent cisplatin-based chemotherapy regimen. Semiquantitative assessment was used to determine maximum and mean SUVs (SUVmax/SUVmean) and metabolic tumor volume (MTV) of the primary tumor. The prognostic significance of PET/CT parameters and other clinical variables was assessed using Cox regression analyses. The cutoffs of PET/CT parameters which have been determined by the previous study were used to separate the groups with Kaplan–Meier curves. Results: Recurrence rates at 1- and 2-y were 18.9% (10/53) and 50.9% (27/53) for all patients, respectively.Cox regression analysis showed that the only prognostic factor for recurrence was a decrease of MTV. Using the cutoff of 29.7%, a decrease of MTV can separate the patients into 2 groups with Kaplan–Meier curve successfully. Conclusion: The use of repeated 18F-FDG PET to assess recurrence during the early stage of CCRT is possible in locally advanced NSCLC patients. A decrease of MTV in 18F-FDG uptake by the primary tumor correlates with higher LRFS.