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Xiulan Su Lan Yu

Xiulan Su Lan Yu

Inner Mongolia Medical University, P.R. China

Title: Association of fourteen PPARr gene SNPs and hypertension in Mongolian population

Biography

Xiulan Su, Master-medicine, now is a Professor of Cell Biology, doctoral supervisor of Inner Mongolia Medical University and Capital University of Medical Science, Director of the Clinical Medical Research Center of the Affi liated Hospital, Inner Mongolia Medical University. Su has been devoted to genetics and metabolic diseases since her graduation in 1998. She participated in establishing two regional key laboratories, and then became director. Su won 9 awards on “Science and Technology Advancement Prize” at provincial or ministerial levels, one award on efforts to develop autonomous region by science, technology and education, a regional “pace-setter” of young scholars, an young outstanding contribution and expert, an young academic leader in health and medical, a regional March 8th red-banner pacesetter. She was chosen as fi rst level in regional “111”, “321” Project. She was named as the famous teacher in Inner Mongolia in 2009. Currently, Su chairs two projects from National Natural Science Foundation. She also chairs and participates in several regional and college research fund projects, one national “863” Project, two Sino-Japan cooperation projects, one Sino-German cooperation project. Su has published 115 papers, including 30 SCI indexed papers. Five students received doctor’s degree and 53 students received master’s degree under supervision from Su.

Abstract

The association of PPARγ polymorphisms with hypertension in several populations is controversial. Th e aim of the present study was to clarify the contributions of PPARγ genetic variants to hypertension through an association study. A total of 385 unrelated Mongolian herdsmen and 523 Han farmers were included in this study. Fourteen SNPs were selected from the Chinese HapMap database based on pairwise r2 ≥ 0.5 with minor allele frequency ≥0.05. Th e SNPs were genotyped using a PCR/ligase detection reaction assay. Prior to correction for multiple testing, the SNP rs6802898 and rs12633551 were signifi cantly related to the prevalence of hypertension in the Han and Mongolian populations, respectively. Th e genetic association of each SNP with hypertension was individually tested using logistic regression. Th e SNP rs6802898 was associated with hypertension in both dominant (P=0.033) and additive models (P=0.026) in Han population, whereas rs12633551were associated with hypertension in both dominant (P=0.014) and additive models (P=0.0073) in the Mongolian population. Moreover, SNP rs12633551 had a signifi cant eff ect on systolic and diastolic blood pressure response. However, none of these associations was statistically signifi cant aft er Bonferroni correction for multiple testing. Th ere was a signifi cant diff erence among the haplotypes in the Han and Mongolian population. Interestingly, there was an association of the PPARγ haplotypes with hypertension even aft er Bonferroni correction. Th us, determination of the PPARγ haplotypes in diff erent populations may prove informative for assessment of the genetic risk for hypertension.

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