Adel Nefzi has completed his from the University of Lausanne in Switzerland and Post-doctoral studies from The Torrey Pines Institute of Molecular Studies, in San Diego, CA. He is the Director of Chemistry at Torrey Pines Institute. He has published more than 120 papers in reputed journals and has more than 10 patents in drug discovey.


The last two decades has witnessed major breakthroughs in the identifi cation of genes, gene products, metabolic pathways, and signaling pathways, as well as progress in miniaturization and robotics, enabling the development of high-throughput mechanism-based biological assays. One of the central objectives of organic and medicinal chemistry is the design, synthesis, and production of molecules having value as human therapeutic agents. Our research group is interested in the design, synthesis, analysis, conformations, dynamics and structure-biological activity relationships of diverse nitrogen heterocycles of diff erent ring sizes. Diaza- and triaza-cyclic compounds with diff erent substitution patterns and embedded in various molecular frameworks constitute important structure classes in the search for bioactivity. Th e compounds are designed to follow known drug-likeness rules including “Lipinski’s Rule of Five”. Examples of the identifi action of highly active compounds will be presnted.

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