Alexander V.Sirotkin

Alexander V.Sirotkin

Research Institute of Animal Production and Constantine the Philosopher University, Slovakia

Title: Food plants and plant molecules affect ovarian functions


A V Sirotkin, PhD, Dr. Sc is working as Professor at the Constantine the Philosopher University, as a Research Scientist at Research Institute of Animal Production in Nitra and as a Visiting Professor at the King Saud University in Riyadh. He has more than 600 publications including 120 full papers in the international journals. He is a member of editorial boards of 4 international journals and a recipient of more than 10 national and international awards.


The aim of our in vitro and in vivo studies was to examine the potential influence of some medical and food plants and their constituents on ovarian functions. For this purpose, we have study the influence of green tea, rooibos, ginkgo, flaxseed, yukka extracts, as well as of plant molecules resveratrol, curcumin, quercetin, daidzein, diosgenin on proliferation, apoptosis, release of hormones and response to gonadotropins of porcine and rabbit ovarian cells as well as on rabbit fecundity. It was observed, that green tea, rooibos, ginkgo, flaxseed, extracts, as well as of resveratrol, curcumin, quercetin, daidzein, diosgenin are able to suppress proliferation, promote apoptosis, to alter the release of steroid hormones and to inhibit the response of cultured ovarian cells to hormonal stimulators FSH and IGF-I. Yukka extract expressed an opposite effect. Furthermore, feeding of rabbits with yukka increased their fecundity. These observations suggest potential direct inhibitory influence of food and medical plants green tea, rooibos, ginkgo, flaxseed on ovarian functions. The similarity in plant and plant constituent effects suggest that the observed plant effects can be due to presence of curcumin, quercetin, daidzein and diosgenin. The potential anti-reproductive effect of these plants should be taken into account by their consummation. On the other hand, yukka can be used as a natural stimulator of reproduction and fecundity.