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Biography

Amany A Salama has completed her Master degree (OB/GYN) 1989, Faculty of Medicine, Alexandria University. Then slightly shifted to study nutrition and its application to women’s health and completed her PhD in Public Health (Nutrition) 2014, High Institute of Public Health, Alexandria University. Works as a Consultant of Women’s Health and Nutrition at Madina Women’s Hospital, Alexandria, Egypt, and a lecturer of clinical nutrition, Faculty of Allied Medical Sciences - Pharos University in Alexandria. Academic research interests: Nutrition – Inflammation - Polycystic ovary syndrome – Oncology.

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disorder with diverse reproductive and metabolic features. Obesity is highly prevalent in the general population and in PCOS women and is an independent risk factor for cardiovascular disease. The study was to investigate the effect of anti-inflammatory diet - in the context of lifestyle modification - with or without the use of metformin in overweight and obese women with PCOS. Out of 220 adult overweight and obese females with PCOS, 150 completed the trial, 75 in each group. Pre and post study fasting blood samples measured biological markers and body composition was assessed by the InBody720. Participants were subjected to either lifestyle interventions with an anti-inflammatory dietary combo and physical activity alone (LS-ONLY) for 12 weeks or with the added use of Metformin 850 mg twice daily (LS+MET). Both strategies achieved moderate weight loss of (±7%) and significant improvements in body composition, hormones and menstrual cyclicity, blood pressure, glucose homeostasis, dyslipidemia, C-reactive protein and serum amyloid A (surrogate measures of cardiovascular risk (CVR)). A 63% regain of menstrual cyclicity and 12% spontaneous pregnancy rate within 12 weeks were achieved. We have found that in overweight and obese women with PCOS, adding metformin to lifestyle modifications at a dose of 850 mg twice daily, had no superior effect to lifestyle modifications alone on; menstrual frequency, pregnancy rates, weight loss, reduction of insulin resistance or reduction of hyperandrogenism. An anti-inflammatory dietary approach with pharmacological targeting can achieve a clinically relevant weight loss in PCOS patients.