Indian Institute of Technology, India
Ms Anju Joshi received her MTech (Nanotechnology) degree from University of Rajasthan, Jaipur in year 2012. She started the pursuit of her PhD degree at the Department of Chemistry, IIT Ropar under the supervision of Dr. Tharamani C.N. in 2013. She has published two papers in peer reviewed journals. Her research interest focuses on development of novel sensors for more effective determination of biomolecules associated with diseased state.
Sensitive and selective determination of dopamine (DA) has drawn considerable attention due to its association with various neurological disorders. However, it is hampered due to presence of ascorbic acid (AA), a common interfering compound in biological fluids whose concentration is 100-1000 times higher than DA. The key point in developing a highly sensitive and selective electrochemical sensor for DA relies on a suitable probe material capable enough to selectively knock down the interference caused due to AA. Nitrogen doped carbonaceous material have shown their enormous potential in determining AA and DA together  but regeneration of DA still remains a formidable task. Here we present, the application of IL (1-butyl 3-methylimidazolium tetrafluroborate (Bmim BF4)) and nitrogen doped carbon nanotubes (NCNTs) based composites for the sensitive and selective determination of DA. For this purpose NCNTs were synthesized by post treatment under NH3 at different temperatures. Square wave voltammetry and rotating disc electrode measurements suggests superior sensitivity and selectivity of NCNTs-IL composites towards the oxidation of DA in presence of higher concentration of ascorbic acid (500 μM). A linear response between the peak current and the concentration of DA has been found to be in the concentration range of 0.001 μM-40 μM and 0.001 μM-10 μM for individual and even in presence of 500 μM respectively.