The University of Texas MD Anderson Cancer Center, USA
Anton Liopo earned his PhD degree from the Institute of Physiology the National Academy of Science (NAS) of Belarus. He later went on to join the Institute of Biochemistry of NAS of Belarus as Senior Scientist, Associate Professor, and eventually the Director of Government Program. After moving to the United States, Dr. Liopo obtained trainings in molecular biology in Department Internal Medicine and nanotechnology in Center for Biomedical Engineering at the University of Texas, Medical Branch at Galveston. He was invited and many years worked in TomoWave Laboratories Inc., where he was Lead Scientist for nanobiotechnology program. Now Dr. Liopo continues his investigations in Center for Radiation Oncology Research, UT MD Anderson Cancer Center, where he is aiming on novel nanocomposites for enhancement of cancer radio-therapy and he is also a visiting scientist in Department of Chemistry of Rice University. Dr. Liopo is a regular reviewer and member of several editorial boards of scientific journals. Dr. Liopo has more than 75 peer-reviewed publications, including monograph, book chapters and patents.
Gold nanoparticles of different shape and size have been designed and applied as contrast-enhancing agents for various imaging techniques: optical coherence tomography, fluorescence imaging, optical microscopy, photoacoustic imaging and sensing; and recently, for experimental cancer therapy as enhancers of thermal and radiation modes. In the current presentation, we are focusing on different sides of gold nanorods (GNRs) applications, as well as their synthesis, functionalization, and specific targeting. The role of GNRs in comprehensive cancer diagnostics and treatment was analyzed. We have created the novel GNRs’ modifications of wide-ranging aspects ratio and size with high yield and quality. The GNRs were assessed by their toxicity for altered categories, such as amount of gold, surface area, optical density of their solutions and number of particles. GNRs have been reviewed as contrast agents with near-infrared absorption as highly efficient transformers of light energy into heat. Here we present the use of GNRs as plasmonic nanoparticles for selective photothermal therapy of human acute and chronicle leukemia cells using a near-infrared laser. We have investigated GNRs as potential enhancers of radiotherapy. We have demonstrated high impact of external surface chemistry, role of molecules size and thickness of surfactant layer for damage of cancer cells by electromagnetic radiation. GNRs were evaluated as theranostic agents for imaging, photothermal and radiation modalities. The results may impact pre-clinical GNRs’ applications, molecular imaging, and quantitative sensing of biological analytes.