Asma Alderaa is a phd student in the University of Nottingham, UK, at her last year. She earn her Master degree from St Gorges univeirty in London in 2011. She
is a Lecturer at King Saude University, KSA. Her main research interest is in multiple sclesrosis and lymphatic system.


Introduction: The prevalence rate of Chronic Lower Limb Oedema (CLLO) in people with MS (pwms) has been
reported to be between 45% and 62% respectively (Solaro et al., 2006; Keeley et al. 2017). Statistical significance was
found between age and Expanded Disability Status Scale (EDSS), where older patients with more disability were
more likely to have oedema (ibid). Evidence of of chronic oedema managements are mainly a specific group related
management or in A form of components treatment where the effectiveness of one component rather than the other
can Not be confirmed. Moreover, evidence related to non-pharmacological intervention in forms of Exercises to treat
CLLO with MS people has not been investigated thoroughly. Therefore, with this Lack of evidence in this area this
study is aimed to assess the effectiveness of progressive resistance Exercise (PRE) in the management of changing
chronic lower limb oedema (CLLO) in people with MS who are resident in Saudi Arabia and to determine the impact
of CLLO on MS patients’ quality Of life.
Methods: Two-hundred and fifty-five pwms and EDSS between 3 to 6.5 were screened from two Hospitals for
CLLO by using a pitting oedema test. Twenty-two were found to have CLLO, However, fifteen out of them agreed
to participate in the study. The participants performed a Biweekly 12-weeks lower limb PRE. The participants
were assessed for any changes in their lower Limb circumference pre and post intervention using a 4 cm interval
circumference which divided the Legs into 6 segments. In addition, Quality of Life (QOL) was measured by using
the Quality of Life Measure for Limb Lymphedema (LYMQOL) tool and Short form of the mcgill Pain Questionnaire
(SF-MPQ) in pre and post intervention.
Results: Fourteen participants completed the intervention with mean age of 44±7.11 years, EDSS 5.6±0.96, BMI
29.08±7.91 and disease onset 12.92±3.7 years. A part from the 5th segment in the Right leg, mean difference volume
reduction was reported in all segments and a greatest reduction Can be seen in the 1st segment -9.11 ml (SD 27.5)
followed by 6th segment -8.57 ml (SD 20.3).However, none of the segments were statistically significant. In the left
leg, again the highest mean Difference volume reduction can be seen in the 2nd segment -5.37 ml (SD 15.5) then
1st -4.51 ml (SD 12.2) and followed by 6th -1.74 ml (SD 30.4). Similar to the right leg, none of the left leg Segments
were statistically significant. In terms of pain and QOL, statistically significant reduction Was reported in the Visual
Analog Scale (VAS) domain P=0.01 and present pain intensity (PPI) Domain P=0.02, and statistically significant
increase in the overall QOL domain P=0.006.
Conclusion: This twelve-week program results demonstrate that PRE has effects on CLLO in terms Of pain and
QOL in pwms. However, no statistically significant was found in the legs volume but Mean difference reduction was
reported at different segments in both legs. More research with Bigger sample size is necessary.