Bharat Bhushan

Bharat Bhushan

Northwestern Feinberg School of Medicine

Title: Metabolic alterations in children with Obstructive sleep apnea


Bharat Bhushan is currently working as a Research Assistant Professor, Department of Otolaryngology head and Neck Surgery, Northwestern University, Chicago & Postdoctoral Research Associate, Division of Otolaryngology, Department of Surgery, Ann & Robert H Lurie Children’s Hospital of Chicago. He has completed his PhD from Department of Medicine, All India Institute of Medical Sciences, New Delhi, India. His thesis work was on the Genetic, Metabolic and Hormonal Profile in obese Asian Indians with Obstructive Sleep Apnea.


Background & Purpose: Obstructive sleep apnea (OSA) is associated with increased risk for metabolic syndrome in both adults and children. Obesity and metabolic syndrome are rapidly increasing in developed countries. Abnormalities of metabolic variables in severity dependent OSA in children has not been investigated to a significant extent.
Methods: Children evaluated in past two years for OSA were included in the study. Components of the metabolic syndrome; total cholesterol, triglyceride, high density lipoprotein-cholesterol (HDL-c), low density lipoprotein-cholesterol (LDL-c) and blood pressure were collected from subject’s medical records. Body mass index (BMI) was calculated using height and weight. OSA was classified as mild (1 Results: 55 Children were included (33 Male and 22 Female) with a mean age of 10.65±4.7 (Mean±SD) years. Seventeen subjects had mild OSA, 23 had moderate/severe OSA, and 15 had no OSA. The mean AHI for mild and moderate/severe OSA was 2.41±1.0 events/hr. and 18.5±17.8 events/hr. respectively. Total cholesterol was higher in moderate/severe OSA (165.8±40.5)mg/dl when compared with no OSA (143.6±32.3)mg/dl p=0.09. Triglyceride levels were significantly higher in moderate/severe OSA (122.1±62.4)mg/dl compared to no OSA (80.4±3.7)mg/dl p=0.03. Systolic blood pressure was significantly increased in moderate/severe OSA (122.2±26.3) when compared with no OSA (108.7±6.8) p=0.02. There was no significant difference in BMI, HDL-c, LDL-c and fasting blood glucose and diastolic blood pressure.
Conclusion: We found that OSA in children adversely affects several of the components associated with metabolic syndrome.

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