Bhimapaka China Raju

CSIR-Indian Institute of Chemical Technology, India

Title: Synthesis and biological activities of 2-chloronicotinaldehyde based novel functionalized heterocyclic compounds


Bhimapaka China Raju completed his PhD from Osmania University and Post-doctoral studies from Prof. H C Brown Center for Borane Research, Purdue University, USA. He is the Senior Scientist of CSIR-IICT, India a premier scientific organization. He has published 66 papers in reputed journals and has been serving as an Editorial Board Member of Oriental Journal of Chemistry, International Journal of Chemistry & Applications and E-Journal of Chemistry.


Heterocyclic compounds and their derivatives are important and are present in many biological systems. Among them, pyridine derivatives have found several applications in the pharmaceutical and agrochemical fields. Extensive studies have been carried out on synthesis of pyridine compounds because of their importance as drugs and natural products. Chloronicotinaldehydes are good precursors for the annulation of variety of heterocyclic analogues. Imidacloprid is the first chloronicotinyl insecticide, used worldwide for controlling pests due to its potency, broad spectrum of insecticidal activity with low mammalian toxicity. Our research group focused on 2-chloronicotinaldehyde based heterocyclic compounds, namely, Imidacloprid analogues, 2-chloro-5-methylpyridine-3-olefin derivatives, 1,8-naphthyridines, Baylis-Hillman (BH) adducts, 1H-1,2,3-triazolylbenzohydrazides, Knoevenagel derivatives, (E) α,β-unsaturated esters, ketones and studied their anti-microbial, anti-mycobacterial and anti-cancer activities. Further, we prepared various 1H-1,2,3-triazoles, 1H-1,2,3-triazolylisoxazoles and 1H-1,2,3-triazolyldihydroisoxazoles starting from 2-chloronicotinaldehydes in combination with TMP and screened for their anti-cancer and anti-tubulin properties.