Russian State Medical University in Moscow, Russia
Bolormaa Vandanmagsar, originally from Ulaanbaatar, Mongolia, graduated Russian State Medical University in Moscow, Russia and got her PhD at the School of Medicine, People’s Friendship University of Russia, Moscow, Russia. Dr. Vandanmagsar completed her postdoctoral training at the School of Medicine, Yonsei University, Seoul, South Korea and National Institute on Aging, NIH, Baltimore, Maryland, USA. Currently she is an Assistant Professor at the Gene-Nutrient Interaction Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA. Her research focuses on obesity, obesity-associated metabolic diseases such as type 2 diabetes, obesity-induced insulin resistance and obesity-associated inflammation.
We evaluated the effectiveness of a weight loss intervention in Mongolian adults with newly diagnosed type 2 diabetes mellitus and with BMIs³25.0 kg/m2, the first study of its kind to be conducted in Mongolia. Eighty participants (33 men/47 women) aged 32-56 years old received education sessions to improve nutritional habits and increase physical activity. Participants were counseled in-person on two occasions with regular follow-up by phone to eat less (reduce calorie intake by 30-40% and consume fewer fatty foods), shift food intake to earlier in a day, and increase physical activity such as walking, jogging, running and biking. After 6 months, the average weight loss was 4.3±4.7 kg, representing a 4.9±5.4 % reduction in body weight (p<0.0001). Mean HbA1c decreased from 8.5±2.7% to 6.0±1.8% (p<0.0001), and the percent of individuals with HbA1c in the diabetic range dropped from 76.3% to 27.5%. These changes were accompanied by marked improvements in cardiovascular risk factors, including total cholesterol (3.92±1.02 to 3.13±0.80 mmol/l; p<0.0001) and triglycerides (2.11±0.82 to 1.54±0.51 mmol/l; p<0.0001), and modest reductions in systolic and diastolic blood pressure (p<0.05). The remarkable improvement in glycemic control and lipid profile in participants suggests that a lifestyle modification intervention targeting weight loss may be highly effective for early diabetes treatment and prevention in Mongolians.