Deniz Arik

Deniz Arik

Eskisehir Osmangazi University, Turkey

Title: Water-clear cell adenoma of the mediastinal parathyroid gland


Deniz ARIK has completed his PhD at the age of 24 years from Hacettepe University and postdoctoral studies from Ankara Numune Research and Teaching Hospital. He has published more than 20 papers in reputed journals.


Water-clear cell adenoma is composed of cells with abundant clear-pink cytoplasm. It is postulated that the water-clear cells are transformed from the chief cells. We report a mediastinal water-clear cell adenoma of the parathyroid gland. At microscopic evaluation, uniform, large clear cells with fine cytoplasmic vacuolization, without nuclear atypia, arranged in solid and acinar patterns were revealed. The cells form nests separated by fine fibrovascular septae and stain positively with anti-parathyroid hormone. Primary hyperparathyroidism is characterized by the autonomous production of parathyroid hormone resulting in hypercalcemia. It is most commonly seen with sporadic adenomas, followed by hyperplasia, multiple adenomas, and carcinoma. Water-clear cell parathyroid adenoma is extremely rare.  There have only 16 cases were reported in the English literature. To the best of our knowledge this has not been reported previously in this localisation. In differential diagnosis of clear cell lesions of the mediastinum, WCCA should be kept in mind.