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Biography

Dong Seok Kim is a Biochemist with special interest in Immunology and Cancer Biology. He holds Ph. D. degree in Biochemistry, specializing in caner-integrin signaling from Yonsei University, Seoul Korea. His research focused on the ubiquitin-mediated regulation of protein expression during T cell activation in NCI, Bethesda MD. He is currently working on new drug development in Peptron and developing therapeutic strategies for neurodegenerative diseases in NIA, Baltimore MD as a collaborator.

Abstract

Exenatide, a glucagon like peptide-1(GLP-1) analogue, has been developed and widely used in clinic as a treatment for type 2 diabetes. Accumulating data also suggest that exenatide as well as other Glp-1R agoinists posess therapeutic potential for the neruodegerative disease such as Alzheimer's disease (AD) and Parkinson’s disease (PD) by neuroprotective and neurotrophic mechanisms, which is investigated in several clinical trials for the treatment of neurodegenerative disorders. SmartDepotTM is Peptron’s proprietary technology for the sustained release (SR) microsphere formulations of various agents to provide once weekly or longer dosing regimens. Peptron is currently developing for type 2 diabetes a SR-Exenatide (once every two weeks), PT302, which is evaluated in a phase 2 clinical trial. In addition, the therapeutic potential of Exenatide in neurodegenerative disorders is being evaluated in various disease models such as AD, PD, HD and TBI. Previously, Exenatide, delivered by a micro-osmotic pump, showed a neuroprotective effects in mild TBI (mTBI) animal model. In this study, the pharmaceutically acceptable sustained release (SR) formulation of exenatide, PT340, was examined in the mTBI mice model. mTBI mice displayed deficits in novel object recognition, while PT340-treated mTBI mice performed similar to sham. These data suggest a strong beneficial action of PT-340 in treating mTBI. Convinient dosing regimen of SR-Exenatide will provide additional benefits for the treatment of the neurodegenerative diseases as well as type 2 diabetes: maximizing therapeutic effects, increasing drug compliance, and extending patent coverage.