Dr. Simon Berkovich

Dr. Simon Berkovich

The George Washington University

Title: On operational determinants of biological processes


Professor Simon Berkovich played a leading role in a number of research and development projects on the design of advanced hardware and software systems. Those projects include construction of superconductive associative memory, development of large information systems, investigation of computer communications configurations, and enhancement of information retrieval procedures. Dr. Berkovich has several hundred professional publications in various areas of physics, electronics, computer science, and biological cybernetics. He is an author of six books and holds 30 patents. He got an award for best invention of 1983 from Bendix Advanced Technology Center and won the 2014 GW Technology Transfer Innovation Competition. Among his inventions is a method for dynamic file construction imitating the developmental tree of multicellular organisms that later become known as B-tree and extendible hashing. In 2002, he was elected a member of the European Academy of Sciences "for an outstanding contribution to computer science and the development of fundamental computational algorithms". Professor Berkovich received an M.S. in Applied Physics from Moscow Physical-Technical Institute and a Ph.D. in Computer Science from the Institute of Precision Mechanics and Computer Technology of the USSR Academy of Sciences.


The central puzzle of Nature is the drastic difference between dead and living matter. Routinely, physics explores dead matter while living matter lies in a completely different realm of biology. A fundamental physical theory that cannot empower the material world with Life is not merely incomplete, it is wrong. Purposeful behavior of complex systems depends on continuous influx of information and energy. With current advancements of information technology such resourceful facilities of Nature can be exemplified in terms of “Cloud Computing” and “Internet of Things”. We have suggested a construction of the physical world using a Cellular Automaton model, which basically displays the behavior of elementary particles of matter. At the next level, it produces the operative capacities of the Holographic Universe exhibiting the inconceivable physical property of nonlocality. This construction incorporates all the tremendous diversity and sophistication of biological phenomena. The suggested worldview shapes the operational capabilities of the genome as the apparatus for organisms’ development. As long as the genome does not contain sufficient amount of information, organisms are built by reference architecture with DNA as classification labels. The pivot process of morphogenesis mobilizes the given resources in a sort of “3-D printing”. Proper understanding of biological information processing is decisive for confronting challenging biomedical situations, in particular, the troublesome antibiotics resistance, which is one of the greatest threats to modern health.