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Elizabeth De Francesco Daher

Elizabeth De Francesco Daher

Federal University of Ceara, Brazil

Title: Tropical Nephropathy

Biography

Graduated in medicine from the Federal University of Ceará, Master of Nephrology at the University of Sao Paulo and a PhD in Nephrology, University of São Paulo. Associate Professor IV of the Federal University of Ceará. Coordinator of the medical of the Faculty of Medicine of the UFC, medical assistance of the General Hospital of Fortaleza and Voluntary Assistance Teacher - University of Miami. She has experience in the area of medicine, focusing on Nephrology, acting on the following topics: acute renal failure in the intensive care unit, renal function in leptospirosis, leprosy, dengue fever, cutaneous leishmaniasis, kala azar and HIV. Professor of Postgraduate Medical Sciences, Department ofl Medicine of UFC Medical School. Fellow researcher at the CNPQ Level 2.

Abstract

It was conducted by the research group on tropical diseases several prospective controlled studies with patients with visceral leishmaniasis, schistosomiasis, leprosy leptospirosis and monitored in outpatient clinics or admitted to tertiary hospitals in Fortaleza, Ceará. To assess glomerular function, the glomerular filtration rate was estimated using the equation and CKD-EPI to plasma creatinine. It measured proteinuria and albuminuria, normalizing values by the urinary creatinine (mg / g-creatinine). The renal tubular function was assessed by: a fractional sodium excretion (FENa +), potassium excretion fraction (FEK +). Were also measured in urine MCP-1, NGAL and KIM-1, novel early biomarkers of renal injury, which were quantified by immunoassay technique of enzyme-linked (ELISA). Urinary biomarkers were normalized by urinary creatinine in the same sample and expressed in "mg / gCreatinina". The concentration of nitric oxide was carried out indirectly through the formation of its stable metabolite. It was also evaluated and endothelial injury through glococálice dosages Syndecam-1 and ICAM-1. The MCP-1 was shown useful as urinary biomarker for detecting subclinical renal dysfunction and as a predictor of long-term kidney disease in tropical diseases. In patients with mild renal damage secondary to leptospirosis, endothelial injury and especially their glycocalyx could be demonstrated by elevated serum levels of syndecan-1 and ICAM-1 and are related to the presence of Acute Kidney Injury.