Filomena Aste Silveira graduated in Medicine, Ph.D. from the Federal University of Rio de Janeiro (UFRJ), and member of the Society of cervical pathology, with title of qualification. Member of the commission of sexually transmitted diseases (STDs), the Brazilian Federation of Gynecology and Obstetrics (FEBRASGO), Prof. Silveira responsible for Gynecology discipline of Valença Medical School (RJ-Brazil). Appraisal professor of gynecology specialist title of proof (TEGO). Medical Institute of Ginecologia- UFRJ - Brazil. Develops research in diseases precursor of cervical cancer and biomarkers, has published some articles in scientific journals.


The low grade cervical intraepithelial squamous lesion (LSIL) is a high prevalence and its behavior is variable. This lesion can minimize, persist or progress. The performance of viral proteins and the epigenetic abnormalities are factors involved in the carcinogenesis of uterine cervix. We studied about the identify the type of HPV-DNA in this lesion and detected the p16INK4a gene methylation too. We analyze the results found about type of HPV-DNA, and methylation then observed with development of LSIL. The time of observation was two years. There was association of oncogenic HPV 16 and 18 with persistence / progression of these lesions. The presence of p16INK4a gene methylation in LSIL was infrequent event and regardless of presence of HPV DNA. We observed that all patients who presented p16INK4a gene methylation showed persistence/progression of this lesion.