Francisco Fábio Oliveira de Sousa

Francisco Fábio Oliveira de Sousa

Federal University of Amapa School of Pharmacy, Brazil

Title: Biopharmaceutical and functional activities improvement by drug-biopolymers association


Francisco Fabio Oliveira de Sousa has completed his PhD from University of Santiago de Compostela, Spain and Postdoctoral studies from Federal University of Ceara School of Dentistry, Brazil. He is the Director of Experimental and Clinical Pharmacy research group with 9 PhD and undergraduate students, coordinating different projects in pharmaceutical technology and biomaterials. He has published more than 10 papers in reputed journals and has been serving as an Editorial Board Member for many journals. In 2018, he has been awarded the Scientifi c Yearly Prize by the Brazilian Council Research


Zein is a biodegradable protein found in the maize endosperm (Zea mays). In the pharmaceutical industry, it has been used as a coating agent in solid forms and in the composition of drug delivery systems, where it has shown the ability to entrap drugs, lipids and genetic material, promoting their controlled release. Its biological potential has gained attention lately. Th us, the antioxidant and antimicrobial activities of zein solely have been identifi ed, but barely explored. Th e associations of biopolymers to drugs could result in synergistic or additive eff ects, depending on the structure, solubility, partition coeffi  cient and chemical interactions to the other compounds, resulting in new outcomes. In view of the biological properties of zein, we assessed the improvement in the antimicrobial and antioxidant activities of this biopolymer when associated to some phenolic bioactive, such as Ellagic Acid (EA). Th eir chemical association was accessed by 1H saturation Transfer-Diff erence Nuclear Magnetic Resonance (STD-NMR) to explain these outcomes. Th e micro dilution method was used to assess the minimum inhibitory and bactericide concentrations. Th e antioxidant activity was determined using the 2, 2-diphenyl-1-picryl-hydrazila free radical scavenging method. EA has shown inhibitory activity against Staphylococcus aureus and Pseudomonas aeruginosa and an antioxidant IC50 of 0.079 mg/mL. Zein has shown antimicrobial and antioxidant activities itself and enhanced synergically the antioxidant and the antimicrobial activity against P. aeruginosa when combined with EA. 1H STD-NMR experiment confi rmed the formation of a complex between EA and zein that could be related with the improvement on its biological performance over the individual compounds