University of Texas Medical Branch, USA
Gwyn Richardson is an Assistant Professor of Gynecologic Oncology at the University of Texas Medical Branch in Galveston TX. She is also the Associate Clerkship Director for the Obstetrics and Gynecology 3rd year Medical School Clerkship. She holds the Francis Eastland Conally Professorship in Gynecologic Oncology
Objective: Among cancer patients, thromboembolic events are a common and potentially fatal complication. This study was designed to determine the incidence of thromboembolic events in relation to the diagnosis, treatment and progression of disease in cervical cancer patients. Study Design: We reviewed records for cervical cancer patients treated at a single institution from 1995-2008. Data collected included demographic characteristics, stage, histologic type, treatment received, time to recurrence, salvage therapy, thromboembolic event and its temporal relationship to cancer diagnosis, and survival. Results: Seven hundred sixty-six patients were diagnosed with invasive cervical cancer during study period. Records were available on 747 patients for mean follow up of 33 months. The incidence of thromboembolic events in cervical cancer patients was 9.0%. Incidence of thromboembolic events was higher in patients with advanced stage. There was no statistically significant difference when accounted by race, smoking history or tumor histology. As expected in patient with advanced stage, treatment modality was related to increased incidence of thromboembolic events. Survival analysis data showed that patients with thromboembolic events had a significantly poorer survival than patients without thromboembolic events. Conclusions: Thromboembolic events at the time of cervical cancer diagnosis are associated with advanced disease and poor prognosis. Following therapy, thromboembolic events may be the first sign of recurrence and confers a grim prognosis.