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Hala Mourad Demerdash

Alexandria University Hospitals, Egypt

Title: Enzymatic changes in obesity-related diseases

Biography

Hala Mourad Demerdash is currently an Associate Professor in the Faculty of Pharmacy, Pharos University in Alexandria (PUA) and Consultant in Clinical Pathology at Alexandria University Hospital. She graduated from the Faculty of Medicine Alexandria University and has received her Master’s degree from Chemical Pathology department, Medical Research Institute and she was a Resident in the Chemical Pathology department from1992-1995. She received her MD from Clinical Pathology Department, Faculty of Medicine, Tanta University in 2007. She was an Associate Professor in 2014 at Tanta University.

Abstract

Obesity is a condition of abnormally increased body fat, resulting from increased energy intake relative to energy expenditure. Obesity is defined as having a body mass index (BMI) of 30 kg/m2 or above, with an increasing incidence in all over the world. Obesity is associated with several health related problems that increase the risk of morbidity and mortality. Scientists have found that enzymes play an important role in obesity-related diseases. They found that at very low, basal levels, enzymes control the threshold of cellular function “signaling pathways”. The purpose of this review is to describe the role of oxidative stress in various obesity related health problems; since obesity is associated with oxidative stress as result of increased oxygen utilization due fat deposition in tissues, increased cardiac load, coupled with oxidative phosphorylation in mitochondria and depletion of ATP and consequent free radical formation. Moreover, high dietary saturated fatty acids (SFA) stimulate intracellular pathways, with more oxidative stress through superoxide generation from NADPH oxidases, glyceraldehyde autoxidation, protein kinase C (PKC) activation, and polyol pathway. In addition, oxidative stress is associated with the infiltration of adipose tissue by inflammatory cells, together with production of high levels of free radical as part of the immune response. Thus obesity is viewed as a chronic inflammatory situation that is critically important in development of pathological states due to tissue damage and altered enzyme activity that result in disease state to extent of tumorigenesis, such as insulin resistance diabetes, cardiovascular disease and kidney dysfunction. It can be concluded that weight reduction in obese subjects improve anti-oxidant defense of body; the triggering factor for series of molecular signals. Also, improving anti-oxidant defense through modulation of dietary pattern or pharmaceutical antioxidants, which may be a potential therapeutic approach in obesity related disease.