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Hani Sheikh Alshabab

Hani Sheikh Alshabab

Aster Hospital
UAE

Title: Cytogenetics in Melanoma/Pathology in point of view

Biography

Hani Sheikh Alshabab is an Syrian Histopathologist graduated from Damascus University in 2003, then he traveled to USA where he achieved my ECFMG certificate, meanwhile he participated in Genomic research related to the genetic role in coronary artery stents stenosis and obesity at Geisinger Health System located in Danville at the beautiful state of  Pennsylvania, then he  moved back to Syria where he enrolled in Anatomic Pathology residency program at Ministry of Health, graduated in 2010, and in 2012 I obtained The Arab Board Certificate/The Fellow Of Arab Board Of Health Specialization Of Pathology (ABHS-Path), with almost 6 years experience in pathology distributed between The General Assembly of Damascus Hospital, private practice, southern Iraq government hospital and finally Aster Hospital in the amazing city of Dubai, UAE. He is a member of Syrian Society of Pathology and Emirates Pathology Society, and have attended many conferences during my career including The Arab Health, Medlab 2016 held in Dubai UAE 2016, Emirates Surgical Pathology Conference held in Dubai UAE 2015, The 23rd Congress of the Arab Division, International Academy of Pathology held in Beirut- Lebanon 2011, and The 12th Meeting of the Syrian Society of Pathology held in Damascus, Syria, 2010 in collaboration with the University of Texas, MD Anderson Cancer Center, Houston

Abstract

  • One person dies of melanoma every hour (every 52 minutes). An estimated 76,380 new cases of invasive melanoma were diagnosed in the U.S. in 2016.  An estimated 10,130 people died of melanoma in 2016. 
  • Melanoma accounts for less than one percent of skin cancer cases, but the vast majority of skin cancer deaths.  
  • The vast majority of melanomas are caused by the sun. In fact, one study found that about 86 percent of melanomas can be attributed to exposure to ultraviolet (UV) radiation from the sun. Regular daily use of an SPF 15 or higher sunscreen reduces the risk of developing melanoma by 50 percent.
  • Naevus number and size established as a heritable factor and a melanoma risk factor.
  • Frequent & consistent chromosomal aberrations with comparative genomic hybridization.
  • Deletions of chromosomes 9p (82%), 10q (63%), and 6q (28%).
  • Genetic differences based on anatomic location and sun exposure. Acral melanomas have more aberrations of chromosomes 5p, 11q, 12q, and 15. Lentigo maligna melanomas show more frequent loss of 17p & 13q.
  • BRAFV600E mutations are frequent in melanocytic naevi, implicating BRAFV600E as an initiating mutation during the evolution of melanoma.
  • Mutations occur during the evolution of melanoma from precursor lesions, and there is an intermediate phase of progression between a naevus and a melanoma.
  • Studies indicating the 18 genetic loci that confer susceptibility to melanoma.
  • UV radiation could generate BRAFV600E mutations which induce a senescence-like state in melanocytes.